in vitro fertilization, levels of pro-inflammatory factors and lipid peroxidation

background: infertility is a problem concerning 10-15% of the individuals in the fertile period. this study investigated effects of proinflammatory factors as well as lipid hydroperoxides (lpo) levels upon in vitro fertilization (ivf) success. materials and methods: in this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before (group-2) and after (group-3) ivf treatment were analyzed. leptin, leptin receptor, resistin, tumor necrosis factor-alpha (tnf-α), and c-reactive protein (crp) were analyzed using enzyme-linked immunosorbent assay (elisa). lpo was determined spectrophotometrically. mann- whitney u test, paired samples t test, wilcoxon signed-rank test as well as pearson correlation analysis by spss were performed for statistical analysis. results: tnf-α, resistin and lpo levels increased (p=0.020, p=0.003, p=0.001, respectively) in group-3 compared to group-2. a significant increase in lpo was noted both in group-2 and -3 compared to controls (p=0.000). lpo were higher in non-pregnants than pregnants in group-2. for pregnants, significant correlations were observed between leptin and resistin in group-2 and tnf-α and leptin in group-3. none of these correlations were found for the women, who could not conceive. conclusion: lpo, leptin-resistin correlation, associations with tnf-α may be helpful during the interpretation of ivf success rates.